CURRICULUM VITAE

February 1998

ARTHUR LOUIS BURNETT, II

Business Address: 407 Marburg Building

Department of Urology

The Johns Hopkins Hospital

600 N. Wolfe Street

Baltimore, Maryland 21287-2411

Telephone: (410) 955-1042, (410) 550-3506

Hyperlink to: http://prostate.urol.jhu.edu/people/faculty/burnett/index.html

EDUCATION

Medical School: Johns Hopkins University School of Medicine

Baltimore, Maryland, M.D., 1988.

Undergraduate: Princeton University, Princeton, New Jersey

A.B., 1984. Major: Biology

High School: St. Anselm's Abbey High School, Washington, D.C.

Diploma, 1980.

LICENSURE AND CERTIFICATION

1990 Maryland State License

1998 Diplomate, American Board of Urology

RESIDENCY TRAINING

July 1990-Dec 1993 Resident, Department of Urology,

Johns Hopkins Hospital, Baltimore, Maryland

July 1989-June 1990 Assistant Resident, Department of Surgery,

Johns Hopkins Hospital, Baltimore, Maryland

July 1988-June 1989 Intern, Department of Surgery,

Johns Hopkins Hospital, Baltimore, Maryland

FELLOWSHIP TRAINING

July 1994-June 1996 Reconstructive Urology and Urodynamics,

Johns Hopkins Hospital, Baltimore, Maryland

Jan 1994-June 1994 Assistant Chief of Service (Instructor in Urology),

Johns Hopkins Hospital, Baltimore, Maryland

MEMBERSHIPS

1998-Present The Society of Genitourinary Reconstructive Surgeons Member

1998-Present American Urogynecologic Society, Member

1997-Present Urodynamics Society, Member

1996-Present International Society for Impotence Research, Member

1994-Present Monumental City Medical Society, Member

1994-Present National Medical Association, Member

1994-Present Society for the Study of Impotence, Member

1991-Present Society of Government Service Urologists, Member

1990-Present American Urological Association, Member

1988-Present American Medical Association, Member

1985-Present Medical and Chirurgical Faculty of the State of Maryland, Member

1984-Present National Association for the Advancement of Colored People, Baltimore Branch, Member

1984-Present Reserve Officers' Association of the United States, Member

1984-Present Sigma Xi Scientific Research Society, Associate Member

1982-Present Ivy Club, Princeton University, Member

HONORS AND AWARDS

1999 Pfizer Scholar in Urology Award

1998 First Prize, American Urological Association/Yamanouchi Best Abstract,

Impotence

1996 Merck Clinician Scientist Award

1996 First Place, Lapides Annual Essay Contest on Urodynamic and Neurourology Research, American Urological Association

1994 Searle New Investigator Research Award, American Foundation for

Urologic Disease, Inc.

1993 Male Reproduction/Urology Prize Paper, American Fertility Society

1993 Second Place, Lapides Annual Essay Contest on Urodynamic and Neurourology Research, American Urological Association

1993 First Place, Laboratory Research, Annual Resident Prize Essay Contest, American Urological Association

1992 First Place, Basic Science, Resident Essay Competition, Mid-Atlantic Section of the American Urological Association

1992 Student Merit Award, American Society of Andrology

1992 The Johns Hopkins University School of Medicine Award for Postdoctoral Investigation, Clinical Science

1985 Summer Research Fellowship Program, Clinical Neurogenetics Branch, National Institute of Mental Health, National Institute of Health,

Warren G. Magnuson Clinical Center, Bethesda, Maryland

1984 Charles M. Cannon Memorial Prize, Biology Department Thesis Symposium, Princeton University

1984 Distinguished Military Graduate, Princeton University, R.O.T.C. Unit

1983 Order of Merit List, R.O.T.C. Advanced Camp, Fort Bragg, North Carolina

UNITED STATES PATENTS

"Treatments for Male Sexual Dysfunction." Patent No. 5,439,938. Granted Aug. 8, 1995. Inventors: Solomon H. Snyder, Arthur L. Burnett, Charles J. Lowenstein, David S. Bredt, Thomas S.K. Chang. Abstract: Methods and devices are taught for regulating penile erection and urethral function. Inhibitors of nitric oxide synthase and precursors of nitric oxide are applied to relax or contract the muscles of the corpus cavernosum and the urethra.

PUBLICATIONS

1. Takahashi, L.K., Lisk, R.D., Burnett, A.L. II: "Dual Estradiol Action in Diencephalon and the Regulation of Socio-sexual Behavior in Female Golden Hamsters." Brain Res., 359 (1985),194-207.

2. Berretini, W.H., Bardakjian, J., Cappelari, C.B., Burnett, A.L., Albright, A., Nurnberger, J.I.,Gershon, E.S.: "Skin Fibroblast Beta-Adrenergic Receptor Function in Manic-Depressive Illness."Biol. Psychiatry, 22 (1987), 1439-43

3. Burnett, A.L., Epstein, J.I., Marshall, F.F.: "Radical Cystectomy for Transitional Cell Carcinoma of the Bladder: Long Term Survival in High Risk Patients." Eur. Urol., 15 (1988), 171-5.

4. Burnett, A.L., Epstein, J.I., Marshall, F.F.: "Adenocarcinoma of Urinary Bladder:Classification and Management." Urology, 37,4 (1991), 315-21.

5. Burnett, A.L., Lowenstein, C.J., Bredt, D.S., Chang, T.S.K., Snyder,

S.H.: "Nitric Oxide: A

Physiologic Mediator of Penile Erection." Science, 257 (1992), 401-3.

6. Burnett, A.L., Chan, D.W., Brendler, C.B., Walsh, P.C.: "The Value of Enzymatic Acid Phosphatase in the Staging of Localized Prostate Cancer." J. Urol., 48 (1992), 1832-4.

7. Burnett, A.L., Tillman, S.L., Chang, T.S.K., Epstein, J.I., Lowenstein, C.J., Bredt, D.S., Snyder, S.H., Walsh, P.C.: "Immunohistochemical Localization of Nitric Oxide Synthase in the Autonomic Innervation of the Human Penis." J. Urol., 150 (1993), 73-6.

8. Burnett, A.L., Epstein, J.I., Gearhart, J.P.: "Spectrum of Differentiation in Pediatric Epithelial Tumors of Kidney: Report of Two Cases." Urology, 42,1 (1993), 93-8.

9. Steiner, M.S., Burnett, A.L., Brooks, J.D., Brendler, C.B., Stutzman, R.E., Carter, H.B.:"Tubularized Neourethra Following Radical Retropubic Prostatectomy." J. Urol., 150 (1993),407-10.

10. Burnett, A.L., Brendler, C.B.: "Femoral Neuropathy Following Major Pelvic Surgery: Etiology and Prevention." J. Urol., 151 (1994), 163-5.

11. Burnett, A.L., Ricker, D.D., Chamness, S.L., Maguire, M.P., Crone, J.K., Bredt, D.S., Snyder,S.H., Chang, T.S.K.: "Localization of Nitric Oxide Synthase in the Reproductive Organs of the Male Rat." Biol. Reprod., 52 (1995), 1-7.

12. Burnett, A.L., Saito, S., Maguire, M.P., Yamaguchi, H., Chang, T.S.K., Hanley, D.F.:"Localization of Nitric Oxide Synthase in Spinal Nuclei Innervating Pelvic Ganglia." J. Urol., 153(1995), 212-7.

13. Gearhart, J.P., Burnett, A.L., Owen, J.H.: "Measurement of Pudendal Evoked Potentials During Feminizing Genitoplasty: Technique and Applications." J. Urol., 153 (1995), 486-7.

14. Burnett, A.L.: "The Role of Nitric Oxide in the Physiology of Erection." Biol. Reprod., 52 (1995),485-9.

15. Burnett, A.L., Maguire, M.P., Chamness, S.L., Ricker, D.D., Takeda, M., Lepor, H., Chang,T.S.K.: "Characterization and Localization of Nitric Oxide Synthase in the Human Prostate."Urology, 45,3 (1995), 435-9.

16. Takeda, M., Tang, R., Shapiro, E., Burnett, A.L., Lepor, H.: "Effects of Nitric Oxide on Human and Canine Prostates." Urology, 45,3 (1995), 440-6.

17. Burnett, A.L., Allen, R.P., Tempany, C.M., Dover, G.J., Brendler, C.B.: "Evaluation of Erectile Function in Men with Sickle Cell Disease." Urology, 45,4 (1995), 657-63.

18. Chamness, S.L., Ricker, D.D., Crone, J.K., Dembeck, C.L., Maguire, M.P., Burnett, A.L., Chang, T.S.K.: "The Effect of Androgen on Nitric Oxide Synthase in the Male Reproductive Tract of the Rat." Fertil. Steril., 63,5 (1995), 1101-7.

19. Burnett, A.L.: "Nitric Oxide Control of Lower Genitourinary Tract Functions: A Review." Urology, 45,6 (1995), 1071-83.

20. Burnett, A.L., Nelson, R.J., Calvin, D.C., Liu, J., Demas, G.E., Klein, S.L., Kriegsfeld, L.J., Dawson, T.M., Snyder, S.H.: "Nitric Oxide Dependent Penile Erection in Mice Lacking Neuronal Nitric Oxide Synthase." Mol. Med., 2,3 (1996), 288-96.

21. Burnett, A.L., Donowitz, M., Marshall, F.F.: "Inhibition of Transport Processes of Intestinal Segments Following Augmentation Enterocystoplasty in Rats." J. Urol., 156 (1996), 1872-5.

22.Wesselmann, U., Burnett, A.L.: "Treatment of Neuropathic Testicular Pain." Neurology (Suppl.)(1996), 206.

23. Burnett, A.L.: "Fascia Lata in Penile Reconstructive Surgery: A Reappraisal of the Fascia Lata Graft." Plas. Reconstr. Surg., 99,4 (1997), 1061-7.

24. Burnett, A.L.: "Nitric Oxide in the Penis: Physiology and Pathology." J. Urol., 157 (1997), 320-4.

25. Padma-Nathan, H., Hellstrom, W.J.G., Kaiser, F.E., et al, for the Medicated Urethral System for Erection (MUSE) Study Group.: "Treatment of Men with Erectile Dysfunction with Transurethral Alprostadil." N. Engl. J. Med., 336 (1997), 1-7.

26. Han, M., Burnett, A.L., Fishman, E.K., Marshall, F.F.: "The Natural History and Treatment of Adrenal Myelolipoma." J. Urol., 157 (1997), 1213-6.

27. Burnett, A.L., Calvin, D.C., Chamness, S.L., Liu, J.-X, Dawson, V.L., Dawson, T.M., Snyder, S.H.: "Urinary Bladder-Urethral Sphincter Dysfunction in Mice with Targeted Disruption of Neuronal Nitric Oxide Synthase Models Idiopathic Voiding Disorders in Humans." Nature Med., 3(1997), 571-4.

28. Burnett, A.L., Calvin, D.C., Silver, R.I., Peppas, D.S., Docimo,S.G.: "Immunohistochemical Description of Nitric Oxide Synthase Isoforms in Human Clitoris." J. Urol., 158 (1997), 75-8.

29. Wesselmann, U., Burnett, A.L., Heinberg, L.J.: "The Urogenital and Rectal Pain Syndromes." Pain 73 (1997), 269-94.

30. Burnett, A.L., Johns, D.G., Kriegsfeld, L.J., Klein, S.L., Calvin, D.C., Demas, G.E., Schramm, L.P., Tonegawa, S., Nelson, R.J.,, Snyder, S.H., Poss, K.D.: "Ejaculatory Abnormalities in Mice with Targeted Disruption of Heme Oxygenase-2." Nature Med. 4 (1998), 84-7.

31. Burnett, A.L.: "Erectile Dysfunction: A Practical Approach For Primary Care." Geriatrics 53 (1998), 34-48.

32. Crone, J.K., Burnett, A.L., Chamness, S.L., Strandberg, J. D., Chang, T. S.: "Neuronal Nitric Aging, Sex Steroid and Pathology Correlations." J. Oxide Synthase in the Canine Prostate; Androl. 19 (1998), 358-364.

33.Burnett, A.L., Mostwin, J.L.: "In Situ Anatomical Study of the Male Urethral Sphincteric Complex: Relevance to Urinary Continence Preservation Following Major Pelvic Surgery." J. Urol. 160(1998), 1301-1306.

34.Klein, S.L., Carnovale, D., Burnett, A.L., Wallach, E.E., Zacur, H.A., Dawson, V.L., Nelson, R.J., Dawson, T.M.: "Impaired Ovulation in Mice with Targeted Deletion of the Neuronal Isoform of Nitric Oxide Synthase." Mol. Med. 4 (1998), 658-664.

35. Althof, S.E., Corty, E.W., Levine, S.B., Seftel, A., Levine, F., Burnett, A.L., McVary, K., Stecher,V.: "The EDITS: The Development of Questionnaires for Evaluating Satisfaction with Treatments for Erectile Dysfunction." Urology 53 (1999), 793-799.

36. Burnett, A.L., Wesselmann, U.: "History of the Neurobiology of the Pelvis." Urology 53 (1999), 1082-1089.

37. Burnett, A.L., Wesselmann, U.: "Neurobiology of the Pelvis and Perineum: Principles for a Practical Approach." J. Pelvic Surgery (1999, in press).

38. Jarow, J.P., Burnett, A.L., Geringer, A.M.: "Clinical Efficacy of Sildenafil Citrate Based upon Etiology and Response to Prior Treatment." J. Urol. (1999, in press).

39. Drazen, D.L., Klein, S.L., Burnett, A.L., Wallach, E.E., Crone, J.K.,Huang, P.L., Nelson, R.J.: "Reproductive Function in Female Mice Lacking the Gene for Endothelial Nitric Oxide Synthase." Neurosci. Lett. (submitted).

40. Kriegsfeld, L.J., Demas,.G.E., Burnett, A.L., Nelson, R.J.: "Ejaculatory Abnormalities in Mice Lacking the Gene for Endothelial Nitric Oxide Synthase (eNOS -/-)Physiol. Behav. (1999, in press).

41. Burnett, A.L.: "Oral Pharmacotherapy for Erectile Dysfunction: Current Perspectives." Urology (1999, in press).

42. Sezen, S.F., Burnett, A.L.: "Intracavernosal Pressure Monitoring in Mice: Responses to Electrical Stimulation of the Cavernous Nerve and to Intracavernosal Drug Administration." J. Androl. (2000, in press).

43. The Consensus Panel on Definition and Classification of Female Sexual Dysfunction.: "Report of the International Consensus Development Conference on Female Sexual Dysfunction: Definitions and Classifications." J. Urol. (submitted).

44. Rowland, D.L., Burnett, A.L.: "Pharmacotherapy in the Treatment of Sexual Dysfunction in Men."J. Sex Research (submitted).

45. Walsh, P.C., Marschke, P., Ricker, D., Burnett, A.L.: "Patient-Reported Urinary Continence and Sexual Function Following Anatomic Radical Prostatectomy." J.A.M.A. (submitted).

46. Walsh, P.C., Marschke, P., Ricker, D., Burnett, A.L. : "The Use of Intraoperative Video Documentation to Improve Sexual Function Following Radical Retropubic Prostatectomy." Urology(submitted)

47. Burnett, A.L., Allen, R.P., Davis, D.M., Wright, D.C., Trueheart, I.N., Chance, B.: "Near Infrared Spectrophotometry for the Diagnosis of Vasculogenic Erectile Dysfunction." J. Urol. (submitted).

BOOK CHAPTERS

1 "Beta-Adrenergic Receptor Function in Human Adult Skin Fibroblasts: A study of

ManicDepressive Illness." In: Clark, S., (Ed.) Receptors, Antidepressants, and Depression. Ciba Foundation, Symposium No. 123, 1986.

2.Mostwin, J.L., Burnett, A.L.: "Anatomic Aspects of Urinary Incontinence." In:

O'Donnell,P.D., (Ed.) Urinary Incontinence. Mosby-Year Book, Inc: St. Louis, MO,1996.

3.Burnett, A.L.: "Neurophysiology of Erectile Function and Dysfunction." In:

Hellstrom, W.,(Ed.) Handbook of Sexual Dysfunction. Allen Press, Inc.: Lawrence,KS, 1999.

4.Wesselmann, U., Burnett, A.L.: "Genitourinary Pain." In: Wall, P.D., Melzack, R.(Eds.)Textbook of Pain, 4 1h Edition. Churchill Livingstone: New York, NY, (1999, in press).

5.Burnett, A.L.: "Significance of the Nitric Oxide Cascade in Erectile Dysfunction."In: Melman, A. (Ed.) Treatment of Erectile Dysfiinction: Clinical and Research Perspectives. Telesymposia Proceedings (1999, in press).

6.Burnett, A.L., Rodriguez,., Jarrett, T.:"Male Anatomy and Physiology". In:

Greenfield, L.J., Mulholland, M.W., Oldham,K.T., Zelenock, G.B., Lillemoe,

K.D.(Eds.) Surgery: Scientific Principles and Practice, 3rd edition.

Lippincott-Raven Publishers: Philadelphia, PA, (1999, in press)

AUDIOVISUAL PRESENTATIONS

Walsh, P.C., Burnett, A.L., Partin, A.W.: "Anatomical Radical Retropubic Prostatectomy: Evolution of the Surgical Technique." American Urological Association National Meeting. San Antonio, Texas. May 15-20, 1993.